Rio Grande

John Wayne

Lt. Col. Kirby Yorke

Maureen O'Hara

Mrs. Kathleen Yorke

Ben Johnson

Trooper Travis Tyree

Claude Jarman Jr.

Trooper Jefferson 'Jeff' Yorke

Harry Carey Jr.

Trooper Daniel 'Sandy' Boone

Chill Wills

Dr. Wilkins

J. Carrol Naish

Lt. Gen. Philip Sheridan

Victor McLaglen

Sgt. Maj. Timothy Quincannon

Grant Withers

U.S. Deputy Marshal

Peter Ortiz

Capt. St. Jacques

Steve Pendleton

Capt. Prescott

Karolyn Grimes

Margaret Mary

Alberto Morin

Lieutenant

Stan Jones

Sergeant

Fred Kennedy

Trooper Heinze

Ken Curtis

Donnelly - Regimental Singer (uncredited)

Tommy Doss

Regimental Singer (uncredited)

Hugh Farr

Regimental Singer (uncredited)

Karl Farr

Regimental Singer (uncredited)

Shug Fisher

Regimental Singer/Bugler (uncredited)