Doctor Detroit

Dan Aykroyd

Clifford Skridlow / Doctor Detroit

Howard Hesseman

Smooth Walker

Donna Dixon

Monica McNeil

Lydia Lei

Jasmine Wu

T.K. Carter

Diavolo Washington

Lynn Whitfield

Thelma Cleland

Fran Drescher

Karen Blittstein

Kate Murtagh

Mom

Nan Martin

Margaret Skridlow

George Furth

Arthur Skridlow

Peter Elbling

Guptor

John A. Maloney

Commodore

Pershing P. Anderson

Stretch

William Munchow

Professor Artel

Ed Meekin

Professor Durant

Hank Salas

Johnny

Rudolph Kovar

Carson

Peter Aykroyd

Mr. Frankman

Glenne Headly

Miss Debbylike

Annabel Armour

Airline Clerk